Advancing Biosecurity & Forensics For All

The Biosecurity and Bioforensics group is part of the Physical and Life Sciences Directorate at Lawrence Livermore National Laboratory that focuses on solving hard problems and developing new and innovative technologies.

Mission: Deliver intelligence-informed, science-based solutions to problems affecting human health and national security.

Vision: Combine cutting-edge sequencing technologies and bioinformatic approaches to develop data-driven models of infection and medical countermeasures.

Our current thrust areas are in:

  • Bioremediation
  • Metagenomic sequencing
  • Bioinformatic analysis of naturally-occurring communities
  • Advanced genetic engineering technologies such as CRISPR/Cas and how they affect cells and organisms

We work with various federal sponsors to deliver high-quality, science-based solutions to constantly-evolving needs.

Our group's core capabilities are:

  • High-throughput sequencing
  • Bioinformatics
  • Development of novel antimicrobials
  • Bioremediation
  • Advanced genetic engineering technologies

We work with various organizations across LLNL to support our sponsors by solving hard problems and developing new and innovative technologies.

We provide subject matter expertise for the intelligence community of potential dual-use technologies, and we partner closely with the Forensic Science Center in Global Security and rely on their expertise in analytical instrumentation and analysis.

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2019

Lyman MG, Urbin S, Strout C, Rubinfeld B. 2019. Book Chapter. The Oleaginous Red Yeast Rhodotorula/Rhodosporidium: A Factory for Industrial Bioproducts. Yeasts in Biotechnology. IntechOpen.

Read: The Oleaginous Red Yeast Rhodotorula/Rhodosporidium: A Factory for Industrial Bioproducts >>

Park DM, Overton KW, Jiao Y (2019) The UzcRS two-component system in Caulobacter crescentus integrates regulatory input from diverse auxiliary regulators. Molecular Microbiology 111(3):678-699. doi: 10.1111/mmi.14180

Read: Caulobacter crescentus >>

2018

Lyman MG, Rubinfeld B, Leif R, Mulcahy H, Dugan L, and Souza B. 2018. Rhodotorula taiwanensis MD1149 Produces Hypoacetylated PEFA Compounds with Increased Surface Activity Compared to Rhodotorula babjevae MD1169. PLoS ONE 13(1): e0190373.

Read: Rhodotorula taiwanensis >>

2017

Park DM, Overton KW, Liou MJ, Jiao Y (2017) Identification of a U/Zn/Cu responsive global regulatory two-component system in Caulobacter crescentus. Molecular Microbiology 104(1):46-64

Read: Molecular Microbiology >>

Tkavc R, Grichenko OE, Matrosova VY, Gostincar C, Volpe RP, Klimenkova P, Gaidamakova EK, Zhou CE, Steward BJ, Lyman MG, Malfatti SA, Rubinfeld B, Singh J, Dalgard CL, Gunde-Cimerman N, Dugan LL, Daly MJ. 2017. Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis. MD1149. Front. Microbiol, 8:2528.

Read Characterization and Genome Sequence of Rhodotorula taiwanensis >>

2016

Grady SL, Malfatti SA, Gunasekera TS, Daley BK, Lyman MG, Striebich RC, Mathew MB, Zhou CL, Ruiz ON, Dugan LC. 2017. A Comprehensive Multi-Omics Approach Uncovers Adaptations for Growth and Survival of Pseudomonas aeruginosa on n-alkanes. BMC Genomics, 18:334.

Read BMC Genomics >>

Overton KW, Park DM, Yung MC, Dohnalkova AC, Smit J, Jiao Y (2016) Two outer membrane proteins contribute to Caulobacter crescentus cellular fitness by preventing intracellular S-layer protein accumulation. Appl Environ Microbiol 82:6961–6972. doi:10.1128/AEM.02479-16

Read Appl Environ Microbiol >>

2015

Yung, MC, Park, DM, Overton, KW, Blow, MJ, Hoover, CA, Smit, J, Murray, SR, Ricci, DP, Christen, B, Bowman, GR, & Jiao, Y (2015) Transposon mutagenesis paired with deep sequencing of Caulobacter crescentus under uranium stress reveals genes essential for detoxification and stress tolerance. J Bacteriol 197:3160-72

Read J Bacteriol >>

Fischer NO, Weilhammer DR, Dunkle A, Thomas C, Hwang M, Corzett M, Lychak C, Urbin S, Collette NC, Chang JC, Loots G, Rasley A, Blanchette C. (2014) Evaluation of Nanolipoprotein Particles (NLPs) as an In Vivo Delivery Platform. PLoS ONE 9(3): e93342. doi:10.1371/journal.pone.0093342

Read PLoS ONE >>